Natural products extracts represent a substantial repository for therapeutics for the treatment of numerous biological conditions. I am interesting in the discovery of novel bioactive macromolecules (such as the antiviral protein Griffithsin) through the interrogation of a unique collection of marine sponges aqueous extracts. The bioactive proteins are low in abundance with a molecular weight range from ~5-50 kD. Sequence similarity searches indicate that the bioactive proteins have little to no sequence homology with known proteins supporting that these molecules represent novel therapeutic classes with tremendous utility against a range of diseases.
Music and Art
Constructive and destructive interference is most fascinating in science, art, and music. From the diffraction patterns from X-ray crystallography to the caustic reflections from a pool of water – interference identifies patterns that result in the solution of a protein structure and rhythms in the abstract music. It is these principals that currently guide my scientific and artistic explorations.
Analog circuitry has a tonal quality that is unmatched by even the most sophisticated algorithms. I create analog synthesizers that use light to pace competing oscillators resulting in the continual generation of sound that is altered by the environment. These competition experiments create a breadth of sound ranging from ambient to crazy noise. The same type of analogue circuitry is also employed in re-creating the awesome raw tones of pre-digital rock.